ABSTRACT
This study was aimed to investigate the effects of Fomes officinalis polysaccharides (FoP) on exercise-induced fatigue and exercise immune suppression in mice with FoP induced by exercise fatigue and unbalanced exercise immunity.Through treadmill exercise,the long-term exercise immune suppression model fatigue was established.Different doses of FoP were used in the animal experiment.The experimental animal were randomly divided into the positive control group,negative control group,low dose FoP (20 mg· kg-1) + exercise group,middle dose FoP (40 mg· kg-1) + exercise group,and the high dose FoP (80 mg· kg-1) + exercise group.The intragastric administration was given 6 days per week for 8 weeks.Treadmill exercise was administered during these 8 weeks.After 8 weeks,the samples were sacrificed.The levels of malondialdehyde (MDA),superoxide dismutase (SOD),hemoglobin (HB) and creatine kinase (CK) were detected by kit.And the relative expression of IL-4mRNA,INF-γmRNA was detected by RT-PCR.The results showed that compared with the positive control group,FoP can significantly improve the level of HB in mice,the level of serum CK in each FoP dose group was significantly decreased;compared with the positive control group,FoP group can significantly eliminate MDA with no significant difference among different FoP dose groups.The contents of SOD in serum of different dose FoP group and the negative control group were significantly higher than that of the positive control group.The IL-4 mRNA/INF-γ mRNA ratio of different dose FoP group were in basic equilibrium.It was concluded that Uygur FoP can effectively promote the body fatigue recovery,accelerate the clearance of free radicals,and improve the antioxidant ability and immune status.